Be aware of changes, never settle on anything and TEST TEST TEST all the time. This is the only way we can prove to ourselves that we are still using the right methods that maximize monetization possibilities.
Specifically speaking on AdSense, a quick tip is to use Google’s DFP (DoubleClick for Publishers) in order to set minimum rates for your various ad locations. The setup process of DFP can be a bit of a learning curve for non-technical website managers but it’s definitely worth the effort and you can always contract a specialist to set it up for you.
Contributor: Rami Yermiya from dignotion.com