Understanding the CDC’s New Covid-19 Guidelines: The End of Quarantine?

Exploring the Updated CDC Quarantine Guidelines for 2022 and What They Mean for the Public

Key Takeaways:

  • The CDC has made significant changes to its Covid-19 guidelines, including the end of required quarantine after exposure to the virus.
  • Under the new guidelines, individuals exposed to Covid-19 no longer need to quarantine but should wear a well-fitting mask and continue to test for at least five days following exposure.
  • Quarantine applies to individuals who have been in close contact with an infected person, while isolation is for those who have been diagnosed with Covid-19.
  • The CDC advises extra precautions for people exposed to the virus when interacting with vulnerable individuals.
  • Isolation guidelines now require a minimum of five days of isolation for individuals with Covid-19, followed by continued masking for an additional five days.
  • Exceptions to the guidelines include individuals with moderate illness, hospitalization, immunocompromised individuals, and those in close contact with medically frail individuals.
  • The CDC suggests testing negative by a rapid antigen test before visiting vulnerable individuals, and testing can be used to shorten the masking period.
  • The changes are a response to the evolving understanding of Covid-19 and the need to balance public health with the resumption of normalcy.


The US Centers for Disease Control and Prevention (CDC) recently made significant updates to its Covid-19 guidelines, including the end of mandatory quarantine for individuals exposed to the virus. These changes have raised questions about the appropriate response to exposure, the duration of isolation for infected individuals, and the rationale behind the new guidelines. To shed light on these updates, we spoke with Dr. Leana Wen, CNN Medical Analyst and an expert in public health.

Understanding Quarantine and Isolation

Quarantine applies to individuals who have been in close contact with someone infected with Covid-19. Previously, quarantine required individuals to stay at home and avoid public settings. However, under the new guidelines, quarantine is no longer necessary. Instead, individuals with exposure should mask for 10 days and continue testing for at least five days after the exposure.

Isolation, on the other hand, is for individuals who have been diagnosed with Covid-19. During isolation, individuals should physically separate themselves from others to prevent further transmission of the virus.

Extra Precautions for Exposed Individuals

While quarantine is no longer required, the CDC advises taking additional precautions when interacting with people who are more susceptible to severe illness from Covid-19. This includes being cautious when visiting elderly relatives or medically frail individuals. It is essential to maintain distance and ensure everyone is wearing masks indoors.

Duration and Testing for Isolation

The new CDC guidelines for isolation have become more nuanced. Individuals diagnosed with Covid-19, whether symptomatic or asymptomatic, should isolate for at least five days. This initial period is when individuals are most contagious. It is crucial to stay home, avoid travel, and not visit places where mask-wearing is not feasible, such as restaurants.

If an individual has no symptoms or if their symptoms are improving, and they remain fever-free for at least 24 hours, isolation can end after five days. However, masking should still be practiced in public settings for an additional five days. This means individuals can return to work but should continue to mask and wear masks while commuting.

Exceptions to the Guidelines

There are exceptions to the general guidelines. Individuals with moderate illness, shortness of breath, difficulty breathing, hospitalization, or compromised immune systems should isolate for a minimum of 10 days. These individuals may have a higher viral load that requires additional time for the virus to clear.

Taking a test to confirm negative status is recommended before visiting medically frail family members or friends. Although not explicitly recommended by the CDC, a negative rapid antigen test can provide added reassurance when interacting with high-risk individuals.

Testing and the “Rebound” Phenomenon

Individuals who test positive again after previously testing negative experience the “rebound” phenomenon. In such cases, the clock resets, and isolation must begin anew. The second positive test marks day zero, and individuals must undergo five days of isolation, followed by continued masking until day 10.

Understanding the Rationale behind the Changes

The updated CDC guidelines reflect the acknowledgment that Covid-19 will remain a part of our lives for the foreseeable future. The focus is on returning to normalcy by reducing disruptive policies. However, additional precautions should be taken when interacting with vulnerable individuals.

The changes are not solely driven by new scientific research but also by the need to align public health recommendations with everyday behavior. Public health must be relevant to gain public trust, and guidelines that are too far removed from everyday practices may lead to skepticism.


The CDC’s revised Covid-19 guidelines, including the end of quarantine and updated isolation protocols, aim to strike a balance between public health and resuming normalcy. The changes reflect an evolving understanding of the virus and the availability of tools to mitigate severe illness. By following the updated guidelines, individuals can contribute to the protection of vulnerable populations and help navigate the ongoing challenges posed by the pandemic.

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