My favorite way to explore a new city, which I often do when on business (but wanting to make it a pleasure trip as well), is by booking a room at a charming B&B in a residential neighborhood, and using either bike share or a rental bike to commute to my conference (usually in the downtown/city center).
This is a great way to actually SEE the city I’m visiting, as I pass by at a slow roll, explore alternate streets and bridges that are bike-friendly (Google maps makes it easy to identify bike-friendly streets in any city), and observe the architecture, people, and bustle of that particular city.
Contributor: Karen Canady from welove2bike.com